How Do Solid-Phase Extraction and Liquid-Liquid Extraction Differ?
While both solid-phase extraction (SPE) and liquid-liquid extraction (LLE) are used for isolating compounds, they differ significantly in their approach. SPE involves passing a liquid sample through a solid adsorbent material that selectively retains the analyte of interest, which is then eluted using a solvent. Conversely, LLE relies on the differential solubility of compounds in two immiscible liquid phases, typically involving solvents. SPE is often preferred for its efficiency, reduced solvent use, and ability to automate the process.
