Toxicologists use various approaches to manage uncertainty:
Uncertainty Factors: These are default values applied to account for data gaps and variability. For example, a common practice is to apply a factor of 10 to account for inter-species differences. Probabilistic Risk Assessment: This approach uses statistical methods to quantify uncertainty and variability, providing a range of possible outcomes rather than a single estimate. Weight of Evidence: By considering multiple lines of evidence, toxicologists can make more informed decisions even when individual studies have limitations. Sensitivity Analysis: This method identifies which variables have the most significant impact on risk assessment outcomes, helping to prioritize data collection and research efforts. Robust Study Designs: Conducting well-designed studies that account for potential sources of variability can help reduce uncertainty.
