Toxins can impact ADH production through several mechanisms. They may damage the cells in the hypothalamus or pituitary gland responsible for producing and storing ADH. Additionally, toxins can disrupt the signaling pathways necessary for the release of ADH in response to changes in the bodyâs water balance. Chronic exposure to certain chemical agents, such as heavy metals or organic solvents, has been linked to alterations in ADH activity, potentially leading to the development of central DI.
