Toxins can have several harmful effects on blood vessels. Some toxins, like those from certain venomous animals, can damage the endothelial lining of the blood vessels, leading to increased permeability and leakage of fluid into surrounding tissues. This can result in edema, hemorrhage, and even collapse of the vascular system. Other toxins may cause vasoconstriction or vasodilation, disrupting normal blood flow and potentially leading to organ damage or failure.