Toxins can affect hexokinase through several mechanisms:
Inhibition: Certain heavy metals like mercury and lead can inhibit hexokinase activity by binding to the enzyme and altering its structure. Oxidative Stress: Some toxins increase oxidative stress, leading to the oxidation of important enzyme residues, which can affect hexokinase function. Gene Expression: Prolonged exposure to toxicants may downregulate or upregulate the expression of hexokinase genes, impacting enzyme levels and activity.
