What are the Consequences of Hexokinase Inhibition?
The inhibition of hexokinase can have several downstream effects:
Energy Deficit: As hexokinase is the first enzyme in the glycolytic pathway, its inhibition can lead to reduced ATP production, causing an energy deficit in cells. Metabolic Imbalance: Disruption in glucose metabolism can lead to an accumulation of glucose and a decrease in glucose-derived metabolites. Cell Death: Severe inhibition may result in apoptosis or necrosis due to energy deprivation.
