The central nervous system (CNS) is often the primary target of toxic substances that induce lethargy. Toxins can alter neurotransmitter levels, disrupt synaptic transmission, or directly damage neuronal cells. For example, carbon monoxide poisoning leads to hypoxia, which can cause lethargy by depriving the brain of oxygen. Similarly, alcohol and certain benzodiazepines can depress CNS activity, leading to lethargy and sedation.
