Volume overload in toxicology can occur through multiple mechanisms:
Renal Impairment: Some toxins can cause acute kidney injury, impairing the body's ability to excrete fluids effectively. Endocrine Disruption: Certain substances interfere with hormonal regulation of fluid balance, such as antidiuretic hormone (ADH) or aldosterone. Direct Fluid Administration: Excessive intravenous fluid administration during treatment of toxic exposure can lead to volume overload.