Various toxins, including certain natural toxins and synthetic chemicals, can bind to tubulin and alter its function. For example, compounds like colchicine and vinca alkaloids bind to tubulin and prevent its polymerization, leading to the depolymerization of microtubules. This disruption can result in the inhibition of mitosis, ultimately causing cell death. Such mechanisms are exploited in cancer therapy but can also cause toxic side effects if not properly controlled.
