nucleic acids

How Do Toxins Interact with Nucleic Acids?

Many toxins can cause direct or indirect damage to nucleic acids. This interaction often leads to mutations, strand breaks, or modifications in the chemical structure of the nucleotides. For instance, alkylating agents can add alkyl groups to nucleic acids, leading to mispairing during DNA replication. Similarly, oxidative stress can result in the formation of 8-oxoguanine, a common oxidative lesion in DNA.

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