How Do Virulence Factors Affect Toxicological Responses?
The virulence factors of Streptococcus pneumoniae, such as its polysaccharide capsule, pneumolysin, and autolysins, play critical roles in disease pathogenesis and can influence toxicological outcomes. The capsule prevents phagocytosis, allowing the bacterium to persist in the host and potentially interact with toxic substances. Pneumolysin's ability to lyse cells and release inflammatory mediators can enhance the toxicity of concomitant exposures, while autolysins contribute to the release of inflammatory cell wall components, further complicating the host's response to toxins.
