Autoinduction occurs when a compound activates the transcription of genes encoding for enzyme systems that metabolize the compound itself. This is typically mediated through nuclear receptors such as the pregnane X receptor (PXR) or the constitutive androstane receptor (CAR), which, upon activation, increase the expression of enzymes like CYP3A4. Over time, this can lead to accelerated drug clearance and reduced plasma concentrations of the drug.
