How Does Chronic Opioid Exposure Affect Receptor Regulation?
Chronic opioid exposure leads to receptor desensitization and downregulation. This process involves the phosphorylation of receptors, which reduces their responsiveness to opioids, contributing to the development of tolerance. As tolerance builds, higher doses are required to achieve the same effect, increasing the risk of overdose and dependency. Understanding these mechanisms is vital for developing strategies to prevent and manage opioid tolerance and addiction.
