Doxycycline toxicity is relatively rare but can occur, particularly with overdose or in individuals with predisposing conditions. Hepatotoxicity is a significant concern, as doxycycline can impair liver function, leading to elevated liver enzymes and, in severe cases, liver failure. Kidney function may also be affected, particularly in patients with pre-existing renal impairment. The drug can cause esophageal irritation or ulceration, particularly when taken without adequate water or before lying down.
