How Does Environmental Exposure Affect MDM2 Expression?
Environmental factors, such as exposure to tobacco smoke, UV radiation, and certain chemicals, can influence MDM2 expression. Such exposures can cause DNA damage, triggering a cellular response that involves the upregulation of MDM2 as part of the feedback loop with p53. Understanding these interactions is crucial for assessing the toxicological risks associated with environmental carcinogens and for developing strategies to mitigate their impact.
