How Does Genetic Variability Influence Toxicological Outcomes?
Genetic variability among individuals can significantly influence toxicological outcomes. Genetic differences can affect how a toxicant is absorbed, distributed, metabolized, and excreted. For instance, variations in cytochrome P450 enzymes can lead to differences in the metabolism of drugs and chemicals, affecting their toxicity. Personalized toxicology aims to account for these genetic differences to better predict individual responses to toxicants.
