How Does MDR1 Interact with Other Drug Transporters?
The MDR1 gene does not act in isolation; it interacts with other drug transporters, such as MRP (Multidrug Resistance-associated Proteins) and BCRP (Breast Cancer Resistance Protein). These interactions can complicate the prediction of drug disposition and resistance. A comprehensive understanding of these interactions is vital for accurately predicting drug responses and designing effective therapies.
