Zymogens, also known as proenzymes, are inactive precursors of enzymes. They require a biochemical change to become active enzymes. This transformation typically involves the cleavage of specific peptide bonds. Zymogens play a crucial role in regulating enzymatic activity within cells and tissues, ensuring that enzymes are activated only when and where they are needed. This mechanism is important in preventing unwanted or premature enzymatic activity that could lead to tissue damage.