Mefloquine works by interfering with the parasite's ability to degrade hemoglobin, a critical process for its survival. It accumulates within the parasite's digestive vacuole, disrupting the polymerization of heme, a toxic byproduct of hemoglobin digestion. This disruption leads to the accumulation of toxic heme, ultimately resulting in the death of the parasite. The precise mechanism of action remains a subject of ongoing research.
