How Does Reduced UGT Activity Affect Drug Metabolism?
When UGT activity is reduced, the metabolism of drugs and other substances can be significantly impaired. This can lead to increased plasma concentrations of drugs, enhancing their pharmacological effects and potential toxicity. For instance, reduced UGT activity can affect the metabolism of analgesics like morphine and acetaminophen, leading to adverse effects or toxicity. It is crucial for healthcare providers to consider UGT activity when prescribing medications that undergo glucuronidation.
