How Does the Route of Administration Impact Toxicity?
The route of administration is a critical factor in determining the toxic potential of a drug. Here are some common routes and their implications:
Oral: Generally, oral drugs undergo first-pass metabolism in the liver, reducing bioavailability but also detoxifying some harmful substances. Inhalation: This route leads to rapid absorption due to the large surface area of the lungs and close proximity to blood vessels, increasing the risk of acute toxicity. Dermal: Skin absorption is generally slow, but lipid-soluble compounds can penetrate more effectively, leading to potential toxicity.
