Thrombin can interact with various drugs, affecting their efficacy and safety. For example, non-steroidal anti-inflammatory drugs (NSAIDs) can affect platelet function, potentially altering thrombin's role in clot formation. Similarly, herbal supplements like ginkgo biloba can have anticoagulant properties that may enhance or diminish the effects of thrombin-targeting drugs. Understanding these interactions is crucial for managing patients on anticoagulation therapy.