Toxicokinetics refers to the study of how a substance is absorbed, distributed, metabolized, and excreted over time. Each of these stages has a specific time frame that can vary depending on the substance and the organism. For instance, a rapidly absorbed toxin will have immediate effects, whereas a slowly metabolized substance may accumulate in the body, leading to delayed toxicity. Biological half-life is a critical parameter that indicates the time required for the concentration of a substance to reduce by half in the body.