Upon ingestion, acrylamide is rapidly absorbed in the gastrointestinal tract and distributed throughout the body. It is metabolized primarily in the liver, where it is either conjugated with glutathione for excretion or converted to glycidamide, an epoxide that is more reactive and potentially more harmful. Glycidamide is believed to be responsible for the genotoxic effects of acrylamide, as it can form DNA adducts, leading to mutations and potentially contributing to cancer development.
