Organ-specific toxicity often arises due to the unique metabolic and physiological functions of different organs. For example: - Hepatotoxicity: The liver is a primary site for detoxification and is vulnerable to damage from metabolites of toxic substances. - Nephrotoxicity: The kidneys filter blood and can accumulate toxicants, leading to renal damage. - Neurotoxicity: The nervous system can be affected by chemicals that alter neurotransmission or damage neurons.