Toxicology is relevant to GVHD in several ways. First, the conditioning regimens involving chemotherapy or radiation therapy used to prepare the recipient for transplant can have toxic side effects. These regimens are designed to suppress the recipient's immune system and create space for the donor cells, but they can also cause damage to tissues, increasing the risk of GVHD. Additionally, the medications used to prevent or treat GVHD, such as immunosuppressants, have their own toxicological profiles that need to be monitored.
