The mainstay of GVHD treatment involves the use of immunosuppressive drugs to dampen the donor immune cell response. Corticosteroids are often the first line of treatment for acute GVHD, while drugs like cyclosporine or tacrolimus are used for long-term management. In some cases, extracorporeal photopheresis, a procedure that modifies the immune response, may be employed. Toxicological monitoring is essential to manage the side effects of these treatments and adjust dosages appropriately.