How Does Variability Affect the Extrapolation of Animal Data to Humans?
Animal studies are a cornerstone of toxicology, but variability presents challenges in extrapolating data to humans. Differences in metabolism, physiology, and genetics between species can lead to varying responses. To address this, toxicologists use uncertainty factors to account for interspecies and intraspecies variability. These factors help bridge the gap between animal data and potential human outcomes.
