Conducting a meta-analysis involves several key steps:
Literature Search: A comprehensive search of scientific literature is performed to identify all relevant studies. Databases like PubMed, Web of Science, and Scopus are commonly used. Selection Criteria: Studies are selected based on predefined criteria, such as type of toxin, study design, and population. Data Extraction: Relevant data from each study is extracted, including sample size, effect sizes, and statistical significance. Statistical Analysis: The extracted data is analyzed using statistical software to calculate a pooled effect size and assess heterogeneity among studies. Interpretation: The results are interpreted in the context of the existing body of evidence, and conclusions are drawn about the overall toxic effects.
