Yes, vitamin B12 can interact with certain medications. For instance, metformin, a common medication for diabetes, can reduce B12 absorption. Proton pump inhibitors (PPIs) used for acid reflux and heartburn can also decrease stomach acid, affecting B12 absorption. Additionally, certain antibiotics and anticonvulsants might interfere with B12 metabolism. It is important for individuals taking these medications to have their B12 levels monitored regularly.