There are several methods to handle censored data in toxicology:
Substitution methods: Replace censored values with a fixed number, such as half the detection limit. While simple, this can introduce bias and is generally not recommended for large datasets. Maximum likelihood estimation (MLE): A statistical approach that accounts for the probability distribution of the data, providing more accurate parameter estimates. Survival analysis techniques: Methods such as Kaplan-Meier or Cox proportional hazards models, which are used to analyze time-to-event data, can also be adapted for dose-response data.
