Once inhaled or ingested, chloroform is rapidly absorbed into the bloodstream and distributed throughout the body. It is primarily metabolized in the liver by the cytochrome P450 enzyme system, leading to the formation of phosgene and other metabolites. These metabolites are believed to contribute to the toxic effects of chloroform, particularly the damage to liver and kidney tissues. The body eventually eliminates chloroform and its metabolites through urine and exhaled air.
