Nephrotoxicity is a major concern with gentamicin use, and it is dose-dependent. Strategies to minimize this risk include careful dosing regimens, monitoring of drug levels in the blood, and ensuring adequate hydration. Therapeutic drug monitoring is critical to maintain gentamicin levels within the therapeutic range while avoiding toxic concentrations. Avoidance of concomitant nephrotoxic drugs and assessing renal function before and during treatment are also essential.
