How do PDE inhibitors affect toxicological outcomes?
PDE inhibitors are a class of drugs that prevent the breakdown of cAMP and cGMP, thereby prolonging their signaling effects. These inhibitors can have therapeutic benefits, such as in the treatment of Pulmonary Hypertension and erectile dysfunction. However, they can also contribute to adverse effects if not properly managed. For instance, excessive inhibition of PDEs can lead to exaggerated physiological responses, such as cardiac arrhythmias or hypotension, highlighting the importance of understanding the Dose-Response Relationship in toxicology.
