Lamotrigine is extensively metabolized in the liver, primarily through glucuronidation. The primary metabolite is an inactive glucuronide conjugate. It is important to note that the metabolism of lamotrigine can be affected by other medications, such as those that induce or inhibit liver enzymes. For instance, enzyme inducers like carbamazepine can increase the clearance of lamotrigine, while inhibitors like valproate can decrease its clearance.
