How is Least Squares Used in Dose-Response Analysis?
Dose-response analysis is a core aspect of toxicology where the response of an organism is measured at different levels of exposure to a substance. The least squares method is employed to fit a dose-response curve, often using models like the linear regression or nonlinear models. By minimizing the residuals between observed and predicted responses, researchers can accurately estimate parameters such as the No Observed Adverse Effect Level (NOAEL) and the Lowest Observed Adverse Effect Level (LOAEL).
