Management of methotrexate toxicity involves both preventive and therapeutic strategies. Leucovorin rescue is a well-established method to mitigate toxic effects by bypassing the inhibited enzyme pathway. Alkalinization of urine and hydration help prevent renal toxicity by enhancing methotrexate excretion. In cases of severe toxicity, treatments like glucarpidase may be employed to rapidly lower methotrexate levels.
