How is Safety Margin Applied in Regulatory Toxicology?
In regulatory toxicology, the safety margin is used to establish safe exposure limits and guidelines for various substances. Regulatory agencies, like the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA), use safety margins to set permissible exposure limits (PELs), reference doses (RfD), and acceptable daily intakes (ADI). These limits are designed to protect both human health and the environment, considering the most sensitive populations.
