Several factors can influence the safety margin of a substance, including:
Population Variability: Different individuals may respond differently to the same dose due to genetic factors, age, sex, and health status. Route of Exposure: The method by which a substance is introduced into the body, such as oral, inhalation, or dermal, can affect its toxicity. Duration of Exposure: Acute versus chronic exposure can influence the observed safety margin, as long-term exposure may lead to cumulative effects. Presence of Other Chemicals: Interactions with other chemicals, known as chemical interactions, can alter the toxicity of a substance.
