What Approaches Are Used to Manage Data Uncertainty?
Several strategies are employed to manage data uncertainty in toxicology:
Use of Safety Factors: Applying default safety factors in risk assessments to account for uncertainties in data. Sensitivity Analysis: Exploring how changes in key assumptions affect the outcome of risk assessments. Probabilistic Risk Assessment: Utilizing statistical methods to quantify uncertainty and variability in risk estimates. Weight-of-Evidence Approaches: Integrating data from multiple sources and types of studies to make informed decisions. Improved Experimental Design: Enhancing study designs to reduce uncertainties, such as using larger sample sizes and appropriate controls.
