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What are Adverse Outcome Pathways (AOPs)?

Adverse Outcome Pathways (AOPs) are conceptual frameworks that describe the progression of a toxicological effect from a molecular-level perturbation to an adverse outcome at the organism or population level. AOPs are valuable in toxicology because they provide a structured way to organize and integrate data, facilitating the understanding of toxicological mechanisms and the prediction of adverse effects. AOPs are used to support regulatory decision-making and the development of alternative testing methods.

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