Myelosuppression: This is the suppression of bone marrow activity, leading to decreased production of blood cells. It increases the risk of infections, anemia, and bleeding. Gastrointestinal Toxicity: Drugs can cause nausea, vomiting, diarrhea, and mucositis, which significantly impact patient quality of life. Cardiotoxicity: Some agents, particularly anthracyclines, can cause irreversible heart damage. Neurotoxicity: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect that can affect sensory and motor nerve function. Nephrotoxicity: Agents like cisplatin can cause kidney damage, necessitating careful monitoring and hydration strategies.