IκB kinase inhibitors are a class of compounds designed to interfere with the IκB kinase (IKK) complex's activity. The IKK complex is critical in the activation of the NF-κB pathway, a key regulator of immune response, inflammation, and cell survival. By inhibiting IKK, these inhibitors prevent the degradation of IκB proteins, thereby inhibiting NF-κB activation and its downstream effects.
