Poly (ADP-ribose) polymerase (PARP) inhibitors are a class of pharmacological inhibitors used in cancer therapy. They function by inhibiting the enzyme PARP, which plays a crucial role in the repair of single-strand DNA breaks. By blocking this repair pathway, PARP inhibitors lead to the accumulation of DNA damage, ultimately resulting in the death of cancer cells, particularly those deficient in other DNA repair mechanisms like BRCA mutations.
