Phase II reactions, also known as conjugation reactions, involve the conjugation of the parent compound or its Phase I metabolite with an endogenous substrate. This process is facilitated by enzymes such as glutathione S-transferase or UDP-glucuronosyltransferase. Common conjugation reactions include glucuronidation, sulfation, and acetylation. These reactions generally increase the water solubility of the compound, making it easier for the body to excrete.
