What Are Some Challenges in Using Binary Outcomes?
While binary outcomes simplify the interpretation of toxicological data, they also present challenges. One significant issue is the potential oversimplification of complex biological interactions, which may lead to inaccurate risk assessments. Additionally, binary outcomes may not capture subtle effects that occur at lower doses, known as low-dose effects. These limitations necessitate complementary methods, such as continuous outcome measures, to provide a more comprehensive understanding of toxicological effects.
