What Are Some Challenges in Using GEO for Toxicology?
While GEO is a powerful resource, there are challenges in utilizing it for toxicological studies:
Data Heterogeneity: GEO contains data from various platforms and experimental designs, which can complicate meta-analysis and cross-study comparisons. Data Quality: Not all datasets are of equal quality; some may have technical biases or incomplete annotations, making careful selection and validation necessary. Complexity of Interpretation: Interpreting the biological significance of gene expression changes requires sophisticated bioinformatics tools and domain expertise.
