What Are Some Challenges in Using Structural Biology in Toxicology?
Despite its advantages, structural biology faces challenges in toxicology, such as the complexity of biological systems and the dynamic nature of molecular interactions. Some toxicants may interact with multiple targets, complicating the analysis. Additionally, obtaining high-resolution structures of membrane proteins or transient complexes remains difficult. Advances in computational modeling and integrative approaches are being developed to overcome these limitations and provide a comprehensive understanding of toxicological processes.
