What Are Some Clinical Implications of UGT Variability?
The variability in UGT enzyme activity has significant clinical implications. It can affect drug dosing, efficacy, and the risk of adverse drug reactions. For example, UGT1A1 polymorphisms are associated with Gilbert's syndrome, a condition characterized by elevated bilirubin levels. Additionally, individuals with certain UGT polymorphisms may have an increased risk of toxicity when exposed to drugs like acetaminophen, due to impaired glucuronidation.
