What Are Some Examples of Genetic Variability Impacting Toxicity?
One well-known example is the genetic polymorphism in the NAT2 gene, which encodes the enzyme N-acetyltransferase 2. Slow acetylators, due to specific NAT2 variants, are at increased risk for adverse effects from certain drugs and carcinogens. Another example is the variation in the ALDH2 gene, affecting the metabolism of [alcohol](https://www.ncbi.nlm.nih.gov/). Individuals with inactive ALDH2 variants may experience severe adverse reactions to alcohol consumption.
